ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adcyap1

Full Name:

adenylate cyclase activating polypeptide 1

Alias:

Pacap

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

9q37

Gene Type:

protein-coding

Human Ortholog:

GeneID: 116 Symbol (Name): ADCYAP1 (adenylate cyclase activating polypeptide 1 (pituitary))

Ortholog Status:

The human GeneID 116 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.37400
Original ID2:		Adcyap1
Fold Change:		1.3
P Value:		0.00701
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005057	receptor signaling protein activity	Molecular Function	ISS
GO:0005179	hormone activity	Molecular Function	IEA
GO:0007218	neuropeptide signaling pathway	Biological Process	NAS (11959368)
GO:0045786	negative regulation of cell cycle	Biological Process	ISS