ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Add1

Full Name:

adducin 1 (alpha)

Alias:

MGC124621

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14q21

Physical Location:

81750429-81808918 on NC_005113.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 118 Symbol (Name): ADD1 (adducin 1 (alpha))

Ortholog Status:

The human GeneID 118 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.34234
Fold Change:		1.17
P Value:		0.00208
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016990.2	NP_058686.2	NC_005113.2 range: 81750429..81808918, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	ISS
GO:0030425	dendrite	Cellular Component	IDA (8624703)
GO:0043197	dendritic spine	Cellular Component	IDA (8624703)
GO:0045202	synapse	Cellular Component	IDA (8624703)
GO:0005198	structural molecule activity	Molecular Function	ISS
GO:0042608	T cell receptor binding	Molecular Function	IDA (15163540)
GO:0006811	ion transport	Biological Process	NAS (8543181)
GO:0007010	cytoskeleton organization and biogenesis	Biological Process	TAS (15163540)