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Gene Information
Gene ID:24180
Symbol:Agtr1a
Full Name:angiotensin II receptor, type 1a
Alias:AT1|AT1A|AT1R
Organism:Rattus norvegicus (Rat)
Chromosome:17
Genetic Location:17q12
Physical Location:40629316-40684982 on NC_005116.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 185    Symbol (Name): AGTR1 (angiotensin II receptor, type 1)
Ortholog Status:The human GeneID 185 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Agtr1a
Fold Change:-1.16
P Value:0.006
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_030985.4NP_112247.2NC_005116.2 range: 40629316..40684982, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005768endosomeCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0005768endosomeCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentIDA
GO:0005886plasma membraneCellular ComponentIDA
GO:0005886plasma membraneCellular ComponentISS
GO:0012505endomembrane systemCellular ComponentIDA (15590154)
GO:0012506vesicle membraneCellular ComponentIDA (12110004)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIMP (12446719)
GO:0031968organelle outer membraneCellular ComponentIDA (15590154)
GO:0031410cytoplasmic vesicleCellular ComponentIDA
GO:0030425dendriteCellular ComponentIDA (15590154)
GO:0016323basolateral plasma membraneCellular ComponentIDA (12110004)
GO:0016021integral to membraneCellular ComponentTAS (11906170)
GO:0031983vesicle lumenCellular ComponentIDA (12110004)
GO:0017046peptide hormone bindingMolecular FunctionIMP (12110004|12446719|15569855)
GO:0004945angiotensin type II receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (16902178)
GO:0004947bradykinin receptor activityMolecular FunctionIEA
GO:0043621protein self-associationMolecular FunctionIMP (12446719)
GO:0004872receptor activityMolecular FunctionIEA
GO:0001596angiotensin type I receptor activityMolecular FunctionISS
GO:0001596angiotensin type I receptor activityMolecular FunctionIMP (12110004|12446719)
GO:0001596angiotensin type I receptor activityMolecular FunctionIEA
GO:0001596angiotensin type I receptor activityMolecular FunctionIDA (11906170)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0001965G-protein alpha-subunit bindingMolecular FunctionIMP (9092554)
GO:0001822kidney developmentBiological ProcessIEA
GO:0001921positive regulation of receptor recyclingBiological ProcessIDA
GO:0001822kidney developmentBiological ProcessISS
GO:0045777positive regulation of blood pressureBiological ProcessIEA
GO:0043627response to estrogen stimulusBiological ProcessIDA (12810582)
GO:0001568blood vessel developmentBiological ProcessIEA
GO:0043524negative regulation of neuron apoptosisBiological ProcessISS
GO:0042756drinking behaviorBiological ProcessISS
GO:0042756drinking behaviorBiological ProcessIEA
GO:0001568blood vessel developmentBiological ProcessISS
GO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinBiological ProcessIEA
GO:0008217regulation of blood pressureBiological ProcessTAS (15569855)
GO:0002035brain renin-angiotensin systemBiological ProcessISS
GO:0002035brain renin-angiotensin systemBiological ProcessIEA
GO:0002019regulation of renal output by angiotensinBiological ProcessISS
GO:0002019regulation of renal output by angiotensinBiological ProcessIEA
GO:0002018renin-angiotensin regulation of aldosterone productionBiological ProcessISS
GO:0002018renin-angiotensin regulation of aldosterone productionBiological ProcessIEA
GO:0002001renin secretion into blood streamBiological ProcessISS
GO:0002001renin secretion into blood streamBiological ProcessIEA
GO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinBiological ProcessISS
GO:0006885regulation of pHBiological ProcessIDA (11906170)
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIMP (9092554|12446719)
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)Biological ProcessIDA (11906170)
GO:0007204elevation of cytosolic calcium ion concentrationBiological ProcessIDA (12110004)
GO:0045777positive regulation of blood pressureBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24180
RGD:2070
Ensembl:ENSRNOG00000018346
dbSNP:Agtr1a