ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aldh1a1

Full Name:

aldehyde dehydrogenase 1 family, member A1

Alias:

AHD2|Aldh1|Aldh2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q51

Physical Location:

223731674-223773284 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 216 Symbol (Name): ALDH1A1 (aldehyde dehydrogenase 1 family, member A1)

Ortholog Status:

The human GeneID 216 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.6132
Original ID2:		Aldh1a1
Fold Change:		1.25
P Value:		0.00039
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022407.3	NP_071852.2	NC_005100.2 range: 223731674..223773284

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0001758	retinal dehydrogenase activity	Molecular Function	IEA
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity	Molecular Function	ISS
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity	Molecular Function	TAS (8543180)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0043065	positive regulation of apoptosis	Biological Process	ISS
GO:0042573	retinoic acid metabolic process	Biological Process	ISS
GO:0008152	metabolic process	Biological Process	IEA
GO:0002072	optic cup morphogenesis involved in camera-type eye development	Biological Process	ISS
GO:0048048	embryonic eye morphogenesis	Biological Process	ISS