ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aldoa

Full Name:

aldolase A

Alias:

Aldo1|RNALDOG5

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q36

Physical Location:

185970657-185974614 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 226 Symbol (Name): ALDOA (aldolase A, fructose-bisphosphate)

Ortholog Status:

The human GeneID 226 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.1774
Original ID2:		Aldoa
Fold Change:		1.11
P Value:		0.00839
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012495.1	NP_036627.1	NC_005100.2 range: 185970657..185974614, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0003674	molecular_function	Molecular Function	ND
GO:0004332	fructose-bisphosphate aldolase activity	Molecular Function	IEA
GO:0004332	fructose-bisphosphate aldolase activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0016829	lyase activity	Molecular Function	IEA
GO:0001666	response to hypoxia	Biological Process	IEP (16930621)
GO:0035094	response to nicotine	Biological Process	IEP (16622831)
GO:0009408	response to heat	Biological Process	IEP (10395295)
GO:0008152	metabolic process	Biological Process	IEA
GO:0006096	glycolysis	Biological Process	IEA
GO:0043627	response to estrogen stimulus	Biological Process	IEP (16339744)