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Gene Information
Gene ID:24239
Symbol:Cacna1c
Full Name:calcium channel, voltage-dependent, L type, alpha 1C subunit
Alias:RATIVS302
Organism:Rattus norvegicus (Rat)
Chromosome:4
Genetic Location:4q42
Physical Location:154895690-155517388 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 775    Symbol (Name): CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit)
Ortholog Status:The human GeneID 775 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cacna1c
Fold Change:-1.2
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012517.2NP_036649.2NC_005103.2 range: 154895690..155517388, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0002095caveolar macromolecular signaling complexCellular ComponentISS
GO:0005891voltage-gated calcium channel complexCellular ComponentIDA (16554304)
GO:0005891voltage-gated calcium channel complexCellular ComponentIEA
GO:0005891voltage-gated calcium channel complexCellular ComponentISS
GO:0005891voltage-gated calcium channel complexCellular ComponentTAS (11604404)
GO:0043198dendritic shaftCellular ComponentISS
GO:0043025cell somaCellular ComponentISS
GO:0042383sarcolemmaCellular ComponentIDA (16483597)
GO:0030018Z discCellular ComponentIDA (15980179)
GO:0014069postsynaptic densityCellular ComponentISS
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005624membrane fractionCellular ComponentISS
GO:0016021integral to membraneCellular ComponentISS
GO:0005624membrane fractionCellular ComponentIDA (16519540)
GO:0005516calmodulin bindingMolecular FunctionISS
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005245voltage-gated calcium channel activityMolecular FunctionIDA (16554304)
GO:0015270dihydropyridine-sensitive calcium channel activityMolecular FunctionISS
GO:0005245voltage-gated calcium channel activityMolecular FunctionIEA
GO:0005245voltage-gated calcium channel activityMolecular FunctionIMP (16483597)
GO:0005245voltage-gated calcium channel activityMolecular FunctionISS
GO:0005245voltage-gated calcium channel activityMolecular FunctionTAS (11604404)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (16483597)
GO:0051721protein phosphatase 2A bindingMolecular FunctionIPI (16519540)
GO:0060083smooth muscle contraction involved in micturitionBiological ProcessISS
GO:0019229regulation of vasoconstrictionBiological ProcessISS
GO:0046620regulation of organ growthBiological ProcessISS
GO:0030073insulin secretionBiological ProcessISS
GO:0030252growth hormone secretionBiological ProcessISS
GO:0042593glucose homeostasisBiological ProcessISS
GO:0017156calcium ion-dependent exocytosisBiological ProcessISS
GO:0008542visual learningBiological ProcessISS
GO:0006816calcium ion transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessIMP (16483597)
GO:0006816calcium ion transportBiological ProcessISS
GO:0006874cellular calcium ion homeostasisBiological ProcessISS
GO:0006939smooth muscle contractionBiological ProcessISS
GO:0007204elevation of cytosolic calcium ion concentrationBiological ProcessISS
GO:0007268synaptic transmissionBiological ProcessISS
GO:0007628adult walking behaviorBiological ProcessISS
GO:0008217regulation of blood pressureBiological ProcessISS
GO:0006811ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:24239
RGD:2245
Ensembl:ENSRNOG00000007090
dbSNP:Cacna1c