ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Camk2d

Full Name:

calcium/calmodulin-dependent protein kinase II, delta

Alias:

CAMK1|Camk2|Camki|MGC124639|RATCAMKI

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q42-q43

Physical Location:

223840649-224111173 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 817 Symbol (Name): CAMK2D (calcium/calmodulin-dependent protein kinase (CaM kinase) II delta)

Ortholog Status:

The human GeneID 817 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Camk2d
Fold Change:		-1.13
P Value:		0.008
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012519.2	NP_036651.1	NC_005101.2 range: 223840649..224111173

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	IPI (8390994)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0030315	T-tubule	Cellular Component	ISS
GO:0004674	protein serine/threonine kinase activity	Molecular Function	ISS
GO:0004683	calmodulin-dependent protein kinase activity	Molecular Function	IDA (11925434)
GO:0046777	protein amino acid autophosphorylation	Biological Process	ISS
GO:0030007	cellular potassium ion homeostasis	Biological Process	IMP (11925434)
GO:0006816	calcium ion transport	Biological Process	ISS
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	ISS
GO:0001666	response to hypoxia	Biological Process	IMP (11925434)
GO:0060048	cardiac muscle contraction	Biological Process	ISS