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Gene Information
Gene ID:24252
Symbol:Cebpa
Full Name:CCAAT/enhancer binding protein (C/EBP), alpha
Alias:DBPCEP
Organism:Rattus norvegicus (Rat)
Chromosome:1
Physical Location:87626110-87627498 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1050    Symbol (Name): CEBPA (CCAAT/enhancer binding protein (C/EBP), alpha)
Ortholog Status:The human GeneID 1050 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cebpa
Fold Change:1.26
P Value:0.005
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012524.2NP_036656.1NC_005100.2 range: 87626110..87627498
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (16172914)
GO:0035189Rb-E2F complexCellular ComponentIDA (16172914)
GO:0016363nuclear matrixCellular ComponentIDA (16172914)
GO:0005667transcription factor complexCellular ComponentISS
GO:0005667transcription factor complexCellular ComponentIDA (12554749)
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0003705RNA polymerase II transcription factor activity, enhancer bindingMolecular FunctionISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0016564transcription repressor activityMolecular FunctionTAS (12020822)
GO:0008134transcription factor bindingMolecular FunctionISS
GO:0042803protein homodimerization activityMolecular FunctionIDA
GO:0016563transcription activator activityMolecular FunctionTAS (12020822)
GO:0042803protein homodimerization activityMolecular FunctionISS
GO:0032403protein complex bindingMolecular FunctionIDA (16172914)
GO:0046982protein heterodimerization activityMolecular FunctionIDA
GO:0003677DNA bindingMolecular FunctionIDA (2850264|12554749|12578822)
GO:0003677DNA bindingMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (8657121)
GO:0031100organ regenerationBiological ProcessIEP (17047332)
GO:0030324lung developmentBiological ProcessISS
GO:0030225macrophage differentiationBiological ProcessISS
GO:0042127regulation of cell proliferationBiological ProcessISS
GO:0033274response to vitamin B2Biological ProcessIEP (16856317)
GO:0045444fat cell differentiationBiological ProcessISS
GO:0045600positive regulation of fat cell differentiationBiological ProcessIMP (11731483)
GO:0048469cell maturationBiological ProcessISS
GO:0051384response to glucocorticoid stimulusBiological ProcessIEP (12753899)
GO:0030154cell differentiationBiological ProcessIEP (16735515)
GO:0030099myeloid cell differentiationBiological ProcessISS
GO:0001889liver developmentBiological ProcessISS
GO:0001892embryonic placenta developmentBiological ProcessISS
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0006350transcriptionBiological ProcessIEA
GO:0006350transcriptionBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIDA (12554749)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessTAS (12578822|12865412)
GO:0006953acute-phase responseBiological ProcessIEP (16172914)
GO:0007005mitochondrion organization and biogenesisBiological ProcessISS
GO:0007584response to nutrientBiological ProcessIEP (16856317)
GO:0008285negative regulation of cell proliferationBiological ProcessISS
GO:0016481negative regulation of transcriptionBiological ProcessIDA (16172914)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0001889liver developmentBiological ProcessIEP (16172914)
Other Database Cross Links
NCBI Entrez Gene:24252
RGD:2326
Ensembl:
dbSNP:Cebpa