ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cftr

Full Name:

cystic fibrosis transmembrane conductance regulator homolog

Alias:

RGD1561193

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q21

Physical Location:

43874561-44040150 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1080 Symbol (Name): CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7))

Ortholog Status:

The human GeneID 1080 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cftr
Fold Change:		-1.13
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_001062374.1	XP_001062374.1	NC_005103.2 range: 43874561..44040150

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016324	apical plasma membrane	Cellular Component	IDA (11083465)
GO:0016324	apical plasma membrane	Cellular Component	ISS
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IDA (11083465)
GO:0003674	molecular_function	Molecular Function	ND
GO:0005515	protein binding	Molecular Function	ISS
GO:0030165	PDZ domain binding	Molecular Function	ISS
GO:0043434	response to peptide hormone stimulus	Biological Process	IEP (16614390)
GO:0042493	response to drug	Biological Process	IEP (16916328)
GO:0042311	vasodilation	Biological Process	IMP (16859673)
GO:0030324	lung development	Biological Process	IMP (15694001)
GO:0030321	transepithelial chloride transport	Biological Process	IMP (17122162)
GO:0007589	body fluid secretion	Biological Process	TAS (11083465)
GO:0043627	response to estrogen stimulus	Biological Process	IEP (16051669)