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Gene Information
Gene ID:24255
Full Name:cystic fibrosis transmembrane conductance regulator homolog
Organism:Rattus norvegicus (Rat)
Genetic Location:4q21
Physical Location:43874561-44040150 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1080    Symbol (Name): CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7))
Ortholog Status:The human GeneID 1080 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cftr
Fold Change:-1.13
P Value:0.005
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_001062374.1XP_001062374.1NC_005103.2 range: 43874561..44040150
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016324apical plasma membraneCellular ComponentIDA (11083465)
GO:0016324apical plasma membraneCellular ComponentISS
GO:0030659cytoplasmic vesicle membraneCellular ComponentIDA (11083465)
GO:0003674molecular_functionMolecular FunctionND
GO:0005515protein bindingMolecular FunctionISS
GO:0030165PDZ domain bindingMolecular FunctionISS
GO:0043434response to peptide hormone stimulusBiological ProcessIEP (16614390)
GO:0042493response to drugBiological ProcessIEP (16916328)
GO:0042311vasodilationBiological ProcessIMP (16859673)
GO:0030324lung developmentBiological ProcessIMP (15694001)
GO:0030321transepithelial chloride transportBiological ProcessIMP (17122162)
GO:0007589body fluid secretionBiological ProcessTAS (11083465)
GO:0043627response to estrogen stimulusBiological ProcessIEP (16051669)
Other Database Cross Links
NCBI Entrez Gene:24255