ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ckb

Full Name:

creatine kinase, brain

Alias:

Ckbb|Ckbr|RATCKBR

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

6q32

Physical Location:

136452214-136455121 on NC_005105.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1152 Symbol (Name): CKB (creatine kinase, brain)

Ortholog Status:

The human GeneID 1152 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ckb
Fold Change:		1.13
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Ckb
Fold Change:		1.13
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012529.2	NP_036661.2	NC_005105.2 range: 136452214..136455121, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	TAS (12093362)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (15094054)
GO:0004111	creatine kinase activity	Molecular Function	TAS (12093362)
GO:0004111	creatine kinase activity	Molecular Function	IEA
GO:0006603	phosphocreatine metabolic process	Biological Process	TAS (12093362)
GO:0007420	brain development	Biological Process	IEP (12093362)
GO:0030644	cellular chloride ion homeostasis	Biological Process	IMP (16336223)