ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Full Name:

ceruloplasmin

Alias:

CERP|RATCERP

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q24

Physical Location:

105086277-105135366 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1356 Symbol (Name): CP (ceruloplasmin (ferroxidase))

Ortholog Status:

The human GeneID 1356 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cp
Fold Change:		-1.3
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012532.1	NP_036664.1	NC_005101.2 range: 105086277..105135366

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	ISS
GO:0046658	anchored to plasma membrane	Cellular Component	IDA (10660599)
GO:0005576	extracellular region	Cellular Component	IDA (10660599)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0004322	ferroxidase activity	Molecular Function	ISS
GO:0005507	copper ion binding	Molecular Function	TAS (10660599)
GO:0005507	copper ion binding	Molecular Function	ISS
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0005507	copper ion binding	Molecular Function	IDA (12099680)
GO:0004322	ferroxidase activity	Molecular Function	TAS (10660599)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006879	cellular iron ion homeostasis	Biological Process	TAS (12099680)
GO:0007568	aging	Biological Process	IEP (16597684)
GO:0007584	response to nutrient	Biological Process	IEP (16597684)
GO:0015679	plasma membrane copper ion transport	Biological Process	TAS (12099680)