ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Klhl21

Full Name:

kelch-like 21 (Drosophila)

Alias:

1810045K06Rik|D330008A20|mKIAA0469

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 E2

Physical Location:

151382999-151391785 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9903 Symbol (Name): KLHL21 (kelch-like 21 (Drosophila))

Ortholog Status:

The human GeneID 9903 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI882440
Note:		Differences expression between alcohol treatment and control groups

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001033352.3	NP_001028524.1	NC_000070.5 range: 151382999..151391785

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005515	protein binding	Molecular Function	IEA