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Gene Information
Gene ID:24330
Full Name:early growth response 1
Organism:Rattus norvegicus (Rat)
Genetic Location:18q
Physical Location:27343566-27347351 on NC_005117.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1958    Symbol (Name): EGR1 (early growth response 1)
Ortholog Status:The human GeneID 1958 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:24330
Fold Change:0.958
P Value:0.029
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012551.2NP_036683.1NC_005117.2 range: 27343566..27347351
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (10837920)
GO:0005634nucleusCellular ComponentISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (10837920)
GO:0003690double-stranded DNA bindingMolecular FunctionIDA (10837920)
GO:0003700transcription factor activityMolecular FunctionIMP (16849326)
GO:0003700transcription factor activityMolecular FunctionISS
GO:0016563transcription activator activityMolecular FunctionIDA (12021067)
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessIMP (16849326)
GO:0045941positive regulation of transcriptionBiological ProcessISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (12021067)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIMP (16849326)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0030217T cell differentiationBiological ProcessISS
GO:0007611learning and/or memoryBiological ProcessIMP (16930406)
GO:0007611learning and/or memoryBiological ProcessIEP (12486186)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0048169regulation of long-term neuronal synaptic plasticityBiological ProcessIMP (16930406)
Other Database Cross Links
NCBI Entrez Gene:24330