ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Egr1

Full Name:

early growth response 1

Alias:

Krox-24|NGFI-A|Ngf1|Ngfi|zif-268

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

18q

Physical Location:

27343566-27347351 on NC_005117.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1958 Symbol (Name): EGR1 (early growth response 1)

Ortholog Status:

The human GeneID 1958 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		24330
Fold Change:		0.958
P Value:		0.029
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012551.2	NP_036683.1	NC_005117.2 range: 27343566..27347351

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (10837920)
GO:0005634	nucleus	Cellular Component	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (10837920)
GO:0003690	double-stranded DNA binding	Molecular Function	IDA (10837920)
GO:0003700	transcription factor activity	Molecular Function	IMP (16849326)
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0016563	transcription activator activity	Molecular Function	IDA (12021067)
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IMP (16849326)
GO:0045941	positive regulation of transcription	Biological Process	ISS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12021067)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IMP (16849326)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0030217	T cell differentiation	Biological Process	ISS
GO:0007611	learning and/or memory	Biological Process	IMP (16930406)
GO:0007611	learning and/or memory	Biological Process	IEP (12486186)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0048169	regulation of long-term neuronal synaptic plasticity	Biological Process	IMP (16930406)