ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Eno1

Full Name:

enolase 1, alpha non-neuron

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q36

Physical Location:

167394635-167405515 on NC_005104.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2023 Symbol (Name): ENO1 (enolase 1, (alpha))

Ortholog Status:

The human GeneID 2023 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.4236
Original ID2:		Eno1
Fold Change:		1.19
P Value:		0.00195
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012554.2	NP_036686.2	NC_005104.2 range: 167394635..167405515

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000015	phosphopyruvate hydratase complex	Cellular Component	IEA
GO:0005575	cellular_component	Cellular Component	ND
GO:0004634	phosphopyruvate hydratase activity	Molecular Function	IEA
GO:0004634	phosphopyruvate hydratase activity	Molecular Function	TAS (16485256)
GO:0005515	protein binding	Molecular Function	ISS
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0006096	glycolysis	Biological Process	IEA
GO:0006096	glycolysis	Biological Process	TAS (16485256)
GO:0030308	negative regulation of cell growth	Biological Process	ISS