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Gene Information
Gene ID:24356
Symbol:Ets1
Full Name:v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
Alias:Ets-1|Etsoncb|MGC124638|Tpl1
Organism:Rattus norvegicus (Rat)
Chromosome:8
Genetic Location:8q21
Physical Location:32477372-32545202 on NC_005107.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2113    Symbol (Name): ETS1 (v-ets erythroblastosis virus E26 oncogene homolog 1 (avian))
Ortholog Status:The human GeneID 2113 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ets1
Fold Change:1.22
P Value:0
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Ets1
Fold Change:1.15
P Value:0.007
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012555.2NP_036687.1NC_005107.2 range: 32477372..32545202
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005667transcription factor complexCellular ComponentISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0016563transcription activator activityMolecular FunctionIDA (12740370)
GO:0045941positive regulation of transcriptionBiological ProcessISS
GO:0045648positive regulation of erythrocyte differentiationBiological ProcessISS
GO:0006916anti-apoptosisBiological ProcessIMP (12740370)
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24356
RGD:2583
Ensembl:ENSRNOG00000008941
dbSNP:Ets1