ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gspt1

Full Name:

G1 to S phase transition 1

Alias:

MGC94063

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q11

Physical Location:

4249195-4283832 on NC_005109.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2935 Symbol (Name): GSPT1 (G1 to S phase transition 1)

Ortholog Status:

The human GeneID 2935 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gspt1
Fold Change:		-1.15
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001003978.1	NP_001003978.1	NC_005109.2 range: 4249195..4283832

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IMP (12865429)
GO:0005515	protein binding	Molecular Function	IDA (12865429)
GO:0003924	GTPase activity	Molecular Function	IEA
GO:0003747	translation release factor activity	Molecular Function	ISS
GO:0006412	translation	Biological Process	TAS (12865429)
GO:0006919	caspase activation	Biological Process	IMP (12865429)
GO:0016567	protein ubiquitination	Biological Process	IMP (12865429)
GO:0042981	regulation of apoptosis	Biological Process	IMP (12865429)
GO:0042981	regulation of apoptosis	Biological Process	IPI (12865429)