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Gene Information
Gene ID:24420
Full Name:G1 to S phase transition 1
Organism:Rattus norvegicus (Rat)
Genetic Location:10q11
Physical Location:4249195-4283832 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2935    Symbol (Name): GSPT1 (G1 to S phase transition 1)
Ortholog Status:The human GeneID 2935 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gspt1
Fold Change:-1.15
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001003978.1NP_001003978.1NC_005109.2 range: 4249195..4283832
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005525GTP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIMP (12865429)
GO:0005515protein bindingMolecular FunctionIDA (12865429)
GO:0003924GTPase activityMolecular FunctionIEA
GO:0003747translation release factor activityMolecular FunctionISS
GO:0006412translationBiological ProcessTAS (12865429)
GO:0006919caspase activationBiological ProcessIMP (12865429)
GO:0016567protein ubiquitinationBiological ProcessIMP (12865429)
GO:0042981regulation of apoptosisBiological ProcessIMP (12865429)
GO:0042981regulation of apoptosisBiological ProcessIPI (12865429)
Other Database Cross Links
NCBI Entrez Gene:24420