ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gstm2

Full Name:

glutathione S-transferase, mu 2

Alias:

GSTA4

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q34

Physical Location:

203549021-203553379 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2946 Symbol (Name): GSTM2 (glutathione S-transferase M2 (muscle))

Ortholog Status:

The human GeneID 2946 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.625
Original ID2:		Gstm2
Fold Change:		1.14
P Value:		0.00315
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_177426.1	NP_803175.1	NC_005101.2 range: 203549021..203553379, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004364	glutathione transferase activity	Molecular Function	IEA
GO:0004364	glutathione transferase activity	Molecular Function	TAS (3020050)
GO:0005515	protein binding	Molecular Function	ISS
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006805	xenobiotic metabolic process	Biological Process	TAS (3020050)
GO:0007608	sensory perception of smell	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0050896	response to stimulus	Biological Process	IEA