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Gene Information
Gene ID:24511
Full Name:integrin beta 1 (fibronectin receptor beta)
Organism:Rattus norvegicus (Rat)
Genetic Location:19q12
Physical Location:58600731-58647404 on NC_005118.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3688    Symbol (Name): ITGB1 (integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12))
Ortholog Status:The human GeneID 3688 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Itgb1
Fold Change:1.17
P Value:0.001
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Itgb1
Fold Change:1.18
P Value:0.001
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017022.2NP_058718.2NC_005118.2 range: 58600731..58647404, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005604basement membraneCellular ComponentIDA (9202984)
GO:0005783endoplasmic reticulumCellular ComponentISS
GO:0005886plasma membraneCellular ComponentISS
GO:0005925focal adhesionCellular ComponentIDA (17157995)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0008305integrin complexCellular ComponentIMP (17118629)
GO:0008305integrin complexCellular ComponentIEA
GO:0008305integrin complexCellular ComponentIDA (17157995)
GO:0008305integrin complexCellular ComponentIC (12639933)
GO:0005624membrane fractionCellular ComponentIDA (9202984|17157995)
GO:0019717synaptosomeCellular ComponentISS
GO:0001669acrosomeCellular ComponentIDA (9202984)
GO:0045121membrane raftCellular ComponentIDA (17157995)
GO:0042470melanosomeCellular ComponentIEA
GO:0042383sarcolemmaCellular ComponentISS
GO:0031594neuromuscular junctionCellular ComponentISS
GO:0042277peptide bindingMolecular FunctionIDA (12639933)
GO:0042802identical protein bindingMolecular FunctionISS
GO:0046982protein heterodimerization activityMolecular FunctionIC (12639933)
GO:0046982protein heterodimerization activityMolecular FunctionIMP (17118629)
GO:0005178integrin bindingMolecular FunctionIMP (17118629)
GO:0005515protein bindingMolecular FunctionIPI (9858254)
GO:0005515protein bindingMolecular FunctionISS
GO:0005178integrin bindingMolecular FunctionISS
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayBiological ProcessIMP (17157995)
GO:0045214sarcomere organizationBiological ProcessISS
GO:0045596negative regulation of cell differentiationBiological ProcessISS
GO:0042685cardioblast cell fate specificationBiological ProcessISS
GO:0001894tissue homeostasisBiological ProcessIMP (17118629)
GO:0001701in utero embryonic developmentBiological ProcessISS
GO:0043410positive regulation of MAPKKK cascadeBiological ProcessIDA (12639933)
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0008284positive regulation of cell proliferationBiological ProcessISS
GO:0007229integrin-mediated signaling pathwayBiological ProcessIEA
GO:0007229integrin-mediated signaling pathwayBiological ProcessIDA (12639933)
GO:0007160cell-matrix adhesionBiological ProcessIEA
GO:0007155cell adhesionBiological ProcessIEA
GO:0010002cardioblast differentiationBiological ProcessISS
GO:0007155cell adhesionBiological ProcessIDA (12639933)
GO:0006874cellular calcium ion homeostasisBiological ProcessIDA (12639933)
GO:0000082G1/S transition of mitotic cell cycleBiological ProcessISS
GO:0051726regulation of cell cycleBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24511