ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mdh1

Full Name:

malate dehydrogenase 1, NAD (soluble)

Alias:

MDL1|Mdhl|Mor2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14q22

Physical Location:

102259129-102273787 on NC_005113.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4190 Symbol (Name): MDH1 (malate dehydrogenase 1, NAD (soluble))

Ortholog Status:

The human GeneID 4190 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.1504
Original ID2:		Mdh1
Fold Change:		1.15
P Value:		0.00007
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_033235.1	NP_150238.1	NC_005113.2 range: 102259129..102273787, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005625	soluble fraction	Cellular Component	IDA (17447164)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0030060	L-malate dehydrogenase activity	Molecular Function	IEA
GO:0030060	L-malate dehydrogenase activity	Molecular Function	IDA (17447164)
GO:0016615	malate dehydrogenase activity	Molecular Function	IDA (2820961)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0051287	NAD binding	Molecular Function	IDA (17447164)
GO:0008152	metabolic process	Biological Process	IEA
GO:0006108	malate metabolic process	Biological Process	IDA (17447164)
GO:0006107	oxaloacetate metabolic process	Biological Process	IDA (17447164)
GO:0019674	NAD metabolic process	Biological Process	IDA (17447164)
GO:0006099	tricarboxylic acid cycle	Biological Process	IEA
GO:0006096	glycolysis	Biological Process	IEA
GO:0006108	malate metabolic process	Biological Process	IEA