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Gene Information
Gene ID:246136
Full Name:mannosidase, alpha, class 2C, member 1
Organism:Rattus norvegicus (Rat)
Genetic Location:8q24
Physical Location:60887363-60898464 on NC_005107.2
Gene Type:protein-coding
Human Ortholog:GeneID: 4123    Symbol (Name): MAN2C1 (mannosidase, alpha, class 2C, member 1)
Ortholog Status:The human GeneID 4123 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Man2c1
Fold Change:1.14
P Value:0.005
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_139256.1NP_640349.1NC_005107.2 range: 60887363..60898464
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentNAS (2211613)
GO:0003824catalytic activityMolecular FunctionIEA
GO:0004559alpha-mannosidase activityMolecular FunctionIDA (2211613)
GO:0004559alpha-mannosidase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005975carbohydrate metabolic processBiological ProcessIEA
GO:0006013mannose metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:246136