ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Man2c1

Full Name:

mannosidase, alpha, class 2C, member 1

Alias:

MGC93158

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q24

Physical Location:

60887363-60898464 on NC_005107.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4123 Symbol (Name): MAN2C1 (mannosidase, alpha, class 2C, member 1)

Ortholog Status:

The human GeneID 4123 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Man2c1
Fold Change:		1.14
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_139256.1	NP_640349.1	NC_005107.2 range: 60887363..60898464

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	NAS (2211613)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004559	alpha-mannosidase activity	Molecular Function	IDA (2211613)
GO:0004559	alpha-mannosidase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0006013	mannose metabolic process	Biological Process	IEA