ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fmo2

Full Name:

flavin containing monooxygenase 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q22

Physical Location:

78546314-78592869 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2327 Symbol (Name): FMO2 (flavin containing monooxygenase 2 (non-functional))

Ortholog Status:

The human GeneID 2327 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fmo2
Fold Change:		-1.21
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_144737.2	NP_653338.2	NC_005112.2 range: 78546314..78592869, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031227	intrinsic to endoplasmic reticulum membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0050660	FAD binding	Molecular Function	IEA
GO:0050661	NADP binding	Molecular Function	IEA
GO:0004499	flavin-containing monooxygenase activity	Molecular Function	IEA
GO:0004497	monooxygenase activity	Molecular Function	ISS
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0006800	oxygen and reactive oxygen species metabolic process	Biological Process	ISS