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Gene Information
Gene ID:246245
Full Name:flavin containing monooxygenase 2
Organism:Rattus norvegicus (Rat)
Genetic Location:13q22
Physical Location:78546314-78592869 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2327    Symbol (Name): FMO2 (flavin containing monooxygenase 2 (non-functional))
Ortholog Status:The human GeneID 2327 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Fmo2
Fold Change:-1.21
P Value:0.007
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_144737.2NP_653338.2NC_005112.2 range: 78546314..78592869, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0031227intrinsic to endoplasmic reticulum membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005792microsomeCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0050660FAD bindingMolecular FunctionIEA
GO:0050661NADP bindingMolecular FunctionIEA
GO:0004499flavin-containing monooxygenase activityMolecular FunctionIEA
GO:0004497monooxygenase activityMolecular FunctionISS
GO:0004497monooxygenase activityMolecular FunctionIEA
GO:0006800oxygen and reactive oxygen species metabolic processBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:246245