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Gene Information
Gene ID:246299
Symbol:Gtf3a
Full Name:general transcription factor III A
Organism:Rattus norvegicus (Rat)
Chromosome:12
Gene Type:protein-coding
Human Ortholog:GeneID: 2971    Symbol (Name): GTF3A (general transcription factor IIIA)
Ortholog Status:The human GeneID 2971 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gtf3a
Fold Change:1.15
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIDA (11814676)
GO:0003723RNA bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIDA (11814676)
GO:0003677DNA bindingMolecular FunctionISS
GO:0003677DNA bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:246299
RGD:619746
Ensembl:
dbSNP:Gtf3a