ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gtf3a

Full Name:

general transcription factor III A

Organism:

Rattus norvegicus (Rat)

Chromosome:

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2971 Symbol (Name): GTF3A (general transcription factor IIIA)

Ortholog Status:

The human GeneID 2971 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gtf3a
Fold Change:		1.15
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IDA (11814676)
GO:0003723	RNA binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IDA (11814676)
GO:0003677	DNA binding	Molecular Function	ISS
GO:0003677	DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA