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Gene Information
Gene ID:246332
Full Name:U2AF homology motif (UHM) kinase 1
Organism:Rattus norvegicus (Rat)
Genetic Location:13q24
Physical Location:86010860-86025964 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 127933    Symbol (Name): UHMK1 (U2AF homology motif (UHM) kinase 1)
Ortholog Status:The human GeneID 127933 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Uhmk1
Fold Change:-1.25
P Value:0.005
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017293.1NP_058989.1NC_005112.2 range: 86010860..86025964, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA
GO:0005737cytoplasmCellular ComponentIDA
GO:0016740transferase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIC
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI
GO:0004674protein serine/threonine kinase activityMolecular FunctionIDA
GO:0003723RNA bindingMolecular FunctionNAS
GO:0007050cell cycle arrestBiological ProcessISS
GO:0018105peptidyl-serine phosphorylationBiological ProcessIDA
GO:0046777protein amino acid autophosphorylationBiological ProcessISS
GO:0046825regulation of protein export from nucleusBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:246332