ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Uhmk1

Full Name:

U2AF homology motif (UHM) kinase 1

Alias:

KIS|Kist|MGC112620

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q24

Physical Location:

86010860-86025964 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 127933 Symbol (Name): UHMK1 (U2AF homology motif (UHM) kinase 1)

Ortholog Status:

The human GeneID 127933 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Uhmk1
Fold Change:		-1.25
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017293.1	NP_058989.1	NC_005112.2 range: 86010860..86025964, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA
GO:0005737	cytoplasm	Cellular Component	IDA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IC
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA
GO:0003723	RNA binding	Molecular Function	NAS
GO:0007050	cell cycle arrest	Biological Process	ISS
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA
GO:0046777	protein amino acid autophosphorylation	Biological Process	ISS
GO:0046825	regulation of protein export from nucleus	Biological Process	ISS