ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pgk1

Full Name:

phosphoglycerate kinase 1

Alias:

MGC105265|Pgk

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

Xq31

Physical Location:

94324141-94340191 on NC_005120.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5230 Symbol (Name): PGK1 (phosphoglycerate kinase 1)

Ortholog Status:

The human GeneID 5230 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.3369
Original ID2:		Pgk1
Fold Change:		2.18
P Value:		0
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Information

Gene Information

Gene Information

Gene Information

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053291.3	NP_445743.2	NC_005120.2 range: 94324141..94340191

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IDA (1834654)
GO:0005625	soluble fraction	Cellular Component	IDA (1834654)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	ISS
GO:0004618	phosphoglycerate kinase activity	Molecular Function	ISS
GO:0004618	phosphoglycerate kinase activity	Molecular Function	IDA (1834654)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	IDA (1834654)
GO:0006096	glycolysis	Biological Process	IEA
GO:0016310	phosphorylation	Biological Process	ISS