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Gene Information
Gene ID:246648
Symbol:Cyp12d1-p
Alias:12D1|CG18240|CG30489|CYP12D1
Organism:Drosophila melanogaster (Fly)
Chromosome:2R
Genetic Location:47D4-47D4
Physical Location:7007609-7009352 on NT_033778.3, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cyp12d1-p
Fold Change:>2
P Value:3.65E-09
Note:Sensitive line>Resistant line
Dataset Information
Name:17973985
Method:Microarray
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_136791.5NP_610635.4NT_033778.3 range: 7007609..7009352, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentISS
GO:0005739mitochondrionCellular ComponentNAS
GO:0004497monooxygenase activityMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionISS
GO:0009055electron carrier activityMolecular FunctionNAS
GO:0020037heme bindingMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:246648
FLYBASE:FBgn0050489