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Dataset Description
  • Dataset Name: 17973985
  • Species: Fly
  • Method: Microarray
  • No. of Genes: 109
  • Phenotype: Ethanol sensitivity
  • Publication: Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
  • Dataset Summary: We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.

    Gene list of this dataset (109 genes)
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    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    36636AttA-51C1-51C1AttA 
    34458CG31872-32A2-32A2CG31872 
    246444CG30083-52C2-52C2CG30083 
    38952Jon66Ci-66C10-66C10Jon66Ci 
    3885644CG34002-75A4-75A4CG34002 
    34291Cyp4e3-30C7-30C7Cyp4e3 
    34898CG15263-35D1-35D1CG15263 
    42337CG17752-92A10-92A10CG17752 
    3346192CG33528-50A14-50B1CG33528 
    34595esc-33A2-33A2eSc 
    42424MtnB-92E12-92E13MtnB 
    43622Jon99Fi-99F6-99F6Jon99Fi 
    32708CG18258-15F3-15F4CG18258 
    34226Try29F-29F7-29F7Try29F 
    45326Lsp2-68F5-68F5LSp2 
    38933CG7194-66C5-66C5CG7194 
    40081Mkp3-75F6-75F6Mkp3 
    32720CG8661-15F7-15F7CG8661 
    318246CG32850-102B3-102B3CG32850 
    39125CG18180-67C3-67C3CG18180 
    32079CG11750-10B5-10B5CG11750 
    33277ia2-21E3-21E3ia2 
    43056CG11893-96C9-96C9CG11893 
    318246CG32850-102B3-102B3CG32850 
    38013mthl8-61A5-61A5mthl8 
    318117CG32613-12D1-12D1CG32613 
    34823CG18095-34F1-34F2CG18095 
    37087CG14500-55B12-55B12CG14500 
    43047CG13656-96C8-96C8CG13656 
    39123CG8329-67C3-67C3CG8329 
    42738unk-94E1-94E2unk 
    33589CG16704-24B1-24B1CG16704 
    40539CG9766-82A1-82A1CG9766 
    50463CG5693-36E3-36E3CG5693 
    43497Obp99b-99B8-99B8Obp99b 
    36047Def-46D9-46D9Def 
    38831Rac2-66A1-66A1Rac2 
    43602CG9682-99E3-99E3CG9682 
    37539CG3290-58D1-58D1CG3290 
    36651NaPi-T-51C5-51C5NaPi-T 
    33665CG15635-25A2-25A2CG15635 
    35022CG6012-36B2-36B2CG6012 
    33749Cyp28d1-25C10-25C10Cyp28d1 
    37482LBR-57F10-57F11LBR 
    36266Damm-48C5-48C5Damm 
    38013mthl8-61A5-61A5mthl8 
    34645CG6583-33D2-33D2CG6583 
    39808CG4998-72E1-72E1CG4998 
    34067cdc14-28C4-28C4CG7134 
    42141CG17803-90C5-90C5CG17803 
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