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Gene Information
Gene ID:42738
Organism:Drosophila melanogaster (Fly)
Genetic Location:94E1-94E2
Physical Location:18977274-18983591 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:unk
Fold Change:>2
P Value:2.71E-06
Note:Resistant line>Sensitive line
Dataset Information
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_176545.1NP_788722.1NT_033777.2 range: 18977274..18983591, complement
NM_176546.1NP_788723.1NT_033777.2 range: 18977274..18983591, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (1339381)
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionNAS (1339381)
GO:0005515protein bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionNAS (1339381)
GO:0002164larval developmentBiological ProcessIMP (1339381)
GO:0008407bristle morphogenesisBiological ProcessIMP (1339381)
GO:0007476imaginal disc-derived wing morphogenesisBiological ProcessIMP (1339381)
GO:0048749compound eye developmentBiological ProcessIMP (1339381)
Other Database Cross Links
NCBI Entrez Gene:42738