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Gene Information
Gene ID:318246
Organism:Drosophila melanogaster (Fly)
Genetic Location:102B3-102B3
Physical Location:335571-342012 on NC_004353.3
Gene Type:protein-coding
Human Ortholog:GeneID: 26994    Symbol (Name): RNF11 (ring finger protein 11)
Ortholog Status:The human GeneID 26994 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG32850
Fold Change:>2
P Value:8.74E-08
Note:Resistant line>Sensitive line
Gene Information
Original ID1:CG32850
Fold Change:>2
P Value:1.66E-08
Note:Resistant line>Sensitive line
Dataset Information
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_166753.2NP_726563.1NC_004353.3 range: 335571..342012
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005515protein bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:318246