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Dataset Description
  • Dataset Name: 17973985
  • Species: Fly
  • Method: Microarray
  • No. of Genes: 109
  • Phenotype: Ethanol sensitivity
  • Publication: Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
  • Dataset Summary: We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.

    Gene list of this dataset (109 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    36636AttA-51C1-51C1AttA 
    34458CG31872-32A2-32A2CG31872 
    246444CG30083-52C2-52C2CG30083 
    38952Jon66Ci-66C10-66C10Jon66Ci 
    3885644CG34002-75A4-75A4CG34002 
    34291Cyp4e3-30C7-30C7Cyp4e3 
    34898CG15263-35D1-35D1CG15263 
    42337CG17752-92A10-92A10CG17752 
    3346192CG33528-50A14-50B1CG33528 
    34595esc-33A2-33A2eSc 
    42424MtnB-92E12-92E13MtnB 
    43622Jon99Fi-99F6-99F6Jon99Fi 
    32708CG18258-15F3-15F4CG18258 
    34226Try29F-29F7-29F7Try29F 
    45326Lsp2-68F5-68F5LSp2 
    38933CG7194-66C5-66C5CG7194 
    40081Mkp3-75F6-75F6Mkp3 
    32720CG8661-15F7-15F7CG8661 
    318246CG32850-102B3-102B3CG32850 
    39125CG18180-67C3-67C3CG18180 
    32079CG11750-10B5-10B5CG11750 
    33277ia2-21E3-21E3ia2 
    43056CG11893-96C9-96C9CG11893 
    318246CG32850-102B3-102B3CG32850 
    38013mthl8-61A5-61A5mthl8 
    318117CG32613-12D1-12D1CG32613 
    34823CG18095-34F1-34F2CG18095 
    37087CG14500-55B12-55B12CG14500 
    43047CG13656-96C8-96C8CG13656 
    39123CG8329-67C3-67C3CG8329 
    42738unk-94E1-94E2unk 
    33589CG16704-24B1-24B1CG16704 
    40539CG9766-82A1-82A1CG9766 
    50463CG5693-36E3-36E3CG5693 
    43497Obp99b-99B8-99B8Obp99b 
    36047Def-46D9-46D9Def 
    38831Rac2-66A1-66A1Rac2 
    43602CG9682-99E3-99E3CG9682 
    37539CG3290-58D1-58D1CG3290 
    36651NaPi-T-51C5-51C5NaPi-T 
    33665CG15635-25A2-25A2CG15635 
    35022CG6012-36B2-36B2CG6012 
    33749Cyp28d1-25C10-25C10Cyp28d1 
    37482LBR-57F10-57F11LBR 
    36266Damm-48C5-48C5Damm 
    38013mthl8-61A5-61A5mthl8 
    34645CG6583-33D2-33D2CG6583 
    39808CG4998-72E1-72E1CG4998 
    34067cdc14-28C4-28C4CG7134 
    42141CG17803-90C5-90C5CG17803 
    41287CG14691-86C5-86C5CG14691 
    32597CalpC-14B13-14B13CalpC 
    31276CG14419-3C2-3C2CG14419 
    42416MtnC-92E4-92E4MtnC 
    39225Cpr67Fb-67F1-67F1CG18348 
    35538CG14590-42A9-42A9CG14590 
    34035Spn7-28B3-28B3Spn7 
    45285Dr-99B3-99B3Dr 
    326270MtnD-92F1-92F1MtnD 
    32420CG9509-13A1-13A1CG9509 
    35050CG18563-36C9-36C9CG18563 
    42313Dl-92A1-92A2Dl 
    33250CG13947-21E2-21E2CG13947 
    34640rho-6-33D2-33D2rho-6 
    50208CG16836-55C4-55C4CG16836 
    34517CG16743-32C1-32C1CG16743 
    35708CG2064-43E9-43E9CG2064 
    42598CG5778-94A2-94A2CG5778 
    40956CG7910-84E10-84E10CG7910 
    35735phr-43E18-43E18phr 
    38129LysP-61F4-61F4LySP 
    35735phr-43E18-43E18phr 
    38788CG32387-65E6-65E7CG32387 
    2768720Cyp12d1-d-47D4-47D4Cyp12d1-d 
    37102CG15067-55C4-55C4CG15067 
    246648Cyp12d1-p-47D4-47D4Cyp12d1-p 
    34467CG17107-32A4-32A4CG17107 
    36098Prx2540-2-47A7-47A7Prx2540-2 
    246399CG30026-47F10-47F10CG30026 
    38402CG14959-63C2-63C3CG14959 
    318238CG32834-59C1-59C1CG32834 
    33696CG2837-25B2-25B3CG2837 
    37130CG10924-55D1-55D2CG10924 
    37421CG15661-57D2-57D2CG15661 
    34052Acp1-28C2-28C2Acp1 
    3355141CG17478--CG17478 
    38633CG5150-64D5-64D5CG5150 
    41217CG34360-85E14-85E14CG33975 
    35216Lectin-galC1-37D6-37D6Lectin-galC1 
    36708Mtk-52A1-52A1Mtk 
    38858PGRP-SD-66A8-66A8PGRP-SD 
    32821Tsf1-17A9-17A9TSf1 
    37599CG4250-58F4-58F4CG4250 
    35774sut1-44A4-44A4Sut1 
    34453Trim9-31F5-32A2Trim9 
    35861PGRP-SC1b-44E2-44E2PGRP-SC1b 
    41330CG4757-86D5-86D5CG4757 
    40838dj-84B2-84B2dj 
    41213CG9459-85E10-85E10CG9459 
    34203CG9463-29F1-29F1CG9463 
    326169CG31883-30B10-30B10CG31883 
    36661Cyp6a23-51D1-51D1Cyp6a23 
    37054CG5770-55B1-55B1CG5770 
    37100IM1-55C4-55C4IM1 
    36486IM10-50A5-50A5IM10 
    35587Cyp6a2-42D1-42D1Cyp6a2 
    37099IM23-55C4-55C4IM23 
    326258CG33109-88A12-88A12CG33109 
    39510CG10725-70B1-70B1CG10725 
    36780Jhe-52E5-52E5Jhe 
    37313CG13422-57A4-57A4CG13422 
    318189CG32751-5D8-5D8CG32751