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Gene Information
Gene ID:32821
Symbol:Tsf1
Alias:143958_at|CG6186|Tf|Trf|anon-EST:Posey265
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:17A9-17A9
Physical Location:18281964-18284376 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:TSf1
Fold Change:>2
P Value:1.68E-07
Note:Sensitive line>Resistant line
Dataset Information
Name:17973985
Method:Microarray
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_078677.2NP_523401.2NC_004354.3 range: 18281964..18284376
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005381iron ion transmembrane transporter activityMolecular FunctionISS
GO:0005381iron ion transmembrane transporter activityMolecular FunctionNAS
GO:0008199ferric iron bindingMolecular FunctionISS
GO:0006826iron ion transportBiological ProcessIEA
GO:0006826iron ion transportBiological ProcessNAS
GO:0006879cellular iron ion homeostasisBiological ProcessISS
GO:0006952defense responseBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:32821
FLYBASE:FBgn0022355