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Gene Information
Gene ID:42313
Symbol:Dl
Alias:0495/20|0926/11|1053/14|1119/09|1304/03|1423/11|1440/11|1485/04|C1|CG3619|CT12133|D|E(ls)2|anon-WO0118547.269|delta|delta D1|dmDelta|l(3)05151|l(3)92Ab|l(3)j8C3
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:92A1-92A2
Physical Location:15128452-15151934 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 28514    Symbol (Name): DLL1 (delta-like 1 (Drosophila))
Ortholog Status:The human GeneID 28514 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dl
Fold Change:>2
P Value:3.24E-05
Note:Sensitive line>Resistant line
Dataset Information
Name:17973985
Method:Microarray
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057916.3NP_477264.1NT_033777.2 range: 15128452..15151934, complement
NM_169853.1NP_732412.1NT_033777.2 range: 15128452..15151934, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIDA (2185893)
GO:0016021integral to membraneCellular ComponentNAS (12612640)
GO:0016021integral to membraneCellular ComponentTAS (10929403)
GO:0035003subapical complexCellular ComponentIDA (17212657)
GO:0030139endocytic vesicleCellular ComponentIDA (17028337)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005912adherens junctionCellular ComponentIDA (17212657)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005112Notch bindingMolecular FunctionTAS (7954795|12879448)
GO:0004871signal transducer activityMolecular FunctionTAS (11494317)
GO:0005112Notch bindingMolecular FunctionIDA (2185893)
GO:0005112Notch bindingMolecular FunctionNAS (11880339)
GO:0005102receptor bindingMolecular FunctionNAS (12612640)
GO:0035155negative regulation of terminal cell fate specification, open tracheal systemBiological ProcessNAS (10684581)
GO:0035111leg joint morphogenesisBiological ProcessIMP (10357895)
GO:0030720oocyte localization during germarium-derived egg chamber formationBiological ProcessIMP (14536057)
GO:0030718germ-line stem cell maintenanceBiological ProcessIMP (17070683|17287246)
GO:0030713ovarian follicle cell stalk formationBiological ProcessIMP (14536057)
GO:0030707ovarian follicle cell developmentBiological ProcessTAS (9642168|10822261)
GO:0030707ovarian follicle cell developmentBiological ProcessIMP (16542414)
GO:0007451dorsal/ventral lineage restriction, imaginal discBiological ProcessTAS (11253649)
GO:0016318ommatidial rotationBiological ProcessNAS (12000787)
GO:0050768negative regulation of neurogenesisBiological ProcessIMP (15452147|16326033)
GO:0035157negative regulation of fusion cell fate specificationBiological ProcessNAS (10684581)
GO:0035286leg segmentationBiological ProcessIMP (10357895)
GO:0048863stem cell differentiationBiological ProcessIMP (17070683)
GO:0048800antennal morphogenesisBiological ProcessIMP (11429287)
GO:0048749compound eye developmentBiological ProcessTAS (10929403)
GO:0048477oogenesisBiological ProcessTAS (11591336)
GO:0048477oogenesisBiological ProcessIMP (14536057)
GO:0048190wing disc dorsal/ventral pattern formationBiological ProcessIMP (16049109)
GO:0046667compound eye retinal cell programmed cell deathBiological ProcessTAS (12006672)
GO:0046331lateral inhibitionBiological ProcessTAS (11932008|12879448|12879451)
GO:0046331lateral inhibitionBiological ProcessNAS (12593977)
GO:0046331lateral inhibitionBiological ProcessIMP (16093323)
GO:0045465R8 cell differentiationBiological ProcessNAS (11880339)
GO:0042676compound eye cone cell fate commitmentBiological ProcessTAS (12419199)
GO:0042067establishment of ommatidial polarityBiological ProcessTAS (12121634)
GO:0045468regulation of R8 cell spacing in compound eyeBiological ProcessNAS (11880339)
GO:0008586imaginal disc-derived wing vein morphogenesisBiological ProcessTAS
GO:0007417central nervous system developmentBiological ProcessNAS
GO:0007399nervous system developmentBiological ProcessNAS (10929403)
GO:0007398ectoderm developmentBiological ProcessTAS (1913825)
GO:0007398ectoderm developmentBiological ProcessNAS
GO:0007314oocyte anterior/posterior axis determinationBiological ProcessTAS (12879448)
GO:0007219Notch signaling pathwayBiological ProcessTAS (7954795)
GO:0007219Notch signaling pathwayBiological ProcessNAS (11880339)
GO:0007219Notch signaling pathwayBiological ProcessIMP (16093323)
GO:0007219Notch signaling pathwayBiological ProcessIGI (16326033)
GO:0007155cell adhesionBiological ProcessTAS (10929403)
GO:0007015actin filament organizationBiological ProcessIMP (16049109)
GO:0001708cell fate specificationBiological ProcessTAS (9642168|11735386)
GO:0007419ventral cord developmentBiological ProcessNAS (12593977)
GO:0007422peripheral nervous system developmentBiological ProcessIMP (8060613)
GO:0007422peripheral nervous system developmentBiological ProcessTAS (11102367)
GO:0008407bristle morphogenesisBiological ProcessIMP (16168983)
GO:0008356asymmetric cell divisionBiological ProcessTAS (15018932)
GO:0008347glial cell migrationBiological ProcessIMP (17157832)
GO:0007498mesoderm developmentBiological ProcessIMP (1913825)
GO:0007480imaginal disc-derived leg morphogenesisBiological ProcessIMP (11429287)
GO:0007476imaginal disc-derived wing morphogenesisBiological ProcessIMP (15829515)
GO:0007475apposition of dorsal and ventral imaginal disc-derived wing surfacesBiological ProcessIMP (9136017)
GO:0007474imaginal disc-derived wing vein specificationBiological ProcessNAS (12717815)
GO:0007464R3/R4 cell fate commitmentBiological ProcessNAS (12414186)
GO:0007460R8 cell fate commitmentBiological ProcessTAS (10929403)
GO:0007424open tracheal system developmentBiological ProcessNAS (10684581)
GO:0007423sensory organ developmentBiological ProcessIMP (16093323)
GO:0001736establishment of planar polarityBiological ProcessNAS (12414186)
Other Database Cross Links
NCBI Entrez Gene:42313
FLYBASE:FBgn0000463