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Gene Information
Gene ID:34595
Organism:Drosophila melanogaster (Fly)
Genetic Location:33A2-33A2
Physical Location:11827179-11829401 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:eSc
Fold Change:>2
P Value:2.32E-08
Note:Resistant line>Sensitive line
Dataset Information
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_058083.2NP_477431.1NT_033779.4 range: 11827179..11829401, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000790nuclear chromatinCellular ComponentISS
GO:0035098ESC/E(Z) complexCellular ComponentIDA (12408863|12408864)
GO:0005634nucleusCellular ComponentIDA (7556071|11124122)
GO:0046974histone lysine N-methyltransferase activity (H3-K9 specific)Molecular FunctionIC (12408863)
GO:0046976histone lysine N-methyltransferase activity (H3-K27 specific)Molecular FunctionIC (12408863|12408864)
GO:0005515protein bindingMolecular FunctionIPI (12697833)
GO:0003677DNA bindingMolecular FunctionISS
GO:0048666neuron developmentBiological ProcessIMP (16547170)
GO:0016571histone methylationBiological ProcessIDA (12408863|12408864)
GO:0016458gene silencingBiological ProcessISS
GO:0016458gene silencingBiological ProcessIMP (11333237)
GO:0016458gene silencingBiological ProcessIGI (11333237)
GO:0007517muscle developmentBiological ProcessIMP (16547170)
GO:0006342chromatin silencingBiological ProcessNAS (7556071)
GO:0006342chromatin silencingBiological ProcessISS
GO:0006342chromatin silencingBiological ProcessIPI (11124122)
GO:0048813dendrite morphogenesisBiological ProcessIMP (16547170)
Other Database Cross Links
NCBI Entrez Gene:34595