| Gene Information |
| Gene ID: | | 34595 |
| Symbol: | | esc |
| Alias: | | CG14941|L41867 |
| Organism: | | Drosophila melanogaster (Fly) |
| Chromosome: | | 2L |
| Genetic Location: | | 33A2-33A2 |
| Physical Location: | | 11827179-11829401 on NT_033779.4, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | eSc | | Fold Change: | | >2 | | P Value: | | 2.32E-08 | | Note: | | Resistant line>Sensitive line |
| | Dataset Information | | Name: | | 17973985 | | Method: | | Microarray | | Phenotype: | | Ethanol sensitivity | | Publication: | | Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed | | Summary: | | We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0000790 | nuclear chromatin | Cellular Component | ISS | |
| GO:0035098 | ESC/E(Z) complex | Cellular Component | IDA (12408863|12408864) | |
| GO:0005634 | nucleus | Cellular Component | IDA (7556071|11124122) | |
| GO:0046974 | histone lysine N-methyltransferase activity (H3-K9 specific) | Molecular Function | IC (12408863) | |
| GO:0046976 | histone lysine N-methyltransferase activity (H3-K27 specific) | Molecular Function | IC (12408863|12408864) | |
| GO:0005515 | protein binding | Molecular Function | IPI (12697833) | |
| GO:0003677 | DNA binding | Molecular Function | ISS | |
| GO:0048666 | neuron development | Biological Process | IMP (16547170) | |
| GO:0016571 | histone methylation | Biological Process | IDA (12408863|12408864) | |
| GO:0016458 | gene silencing | Biological Process | ISS | |
| GO:0016458 | gene silencing | Biological Process | IMP (11333237) | |
| GO:0016458 | gene silencing | Biological Process | IGI (11333237) | |
| GO:0007517 | muscle development | Biological Process | IMP (16547170) | |
| GO:0006342 | chromatin silencing | Biological Process | NAS (7556071) | |
| GO:0006342 | chromatin silencing | Biological Process | ISS | |
| GO:0006342 | chromatin silencing | Biological Process | IPI (11124122) | |
| GO:0048813 | dendrite morphogenesis | Biological Process | IMP (16547170) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 34595 |
| FLYBASE: | | FBgn0000588 |
