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Gene Information
Gene ID:34067
Organism:Drosophila melanogaster (Fly)
Genetic Location:28C4-28C4
Physical Location:7802486-7810696 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8556    Symbol (Name): CDC14A (CDC14 cell division cycle 14 homolog A (S. cerevisiae))
Ortholog Status:The human GeneID 8556 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG7134
Fold Change:>2
P Value:3.02E-07
Note:Resistant line>Sensitive line
Dataset Information
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_135309.1NP_609153.1NT_033779.4 range: 7802486..7810696, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004725protein tyrosine phosphatase activityMolecular FunctionIEA
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionIEA
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionNAS (10908587)
GO:0006470protein amino acid dephosphorylationBiological ProcessIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessNAS (10908587)
Other Database Cross Links
NCBI Entrez Gene:34067