ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cyp12d1-d

Alias:

12D1|CG18239|CG18240|CG33503|CT26082|CYP12D1|Cyp12d2

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

47D4-47D4

Physical Location:

7011158-7013118 on NT_033778.3, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cyp12d1-d
Fold Change:		>2
P Value:		1.16E-09
Note:		Sensitive line>Resistant line

Dataset Information

Name:		17973985
Method:		Microarray
Phenotype:		Ethanol sensitivity
Publication:		Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:		We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_206090.1	NP_995812.1	NT_033778.3 range: 7011158..7013118, complement

Gene Ontology (GO) Annotation