Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:38831
Alias:CG8556|D-Rac 2|D-Rac2|DRac2|DRacB|DmRAC2|Drac1b|Rac|Rac GTPase|Rac-2|Rac1b|RacB|RacB mRNA.
Organism:Drosophila melanogaster (Fly)
Genetic Location:66A1-66A1
Physical Location:7426988-7428278 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rac2
Fold Change:>2
P Value:3.40E-08
Note:Resistant line>Sensitive line
Dataset Information
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_139864.1NP_648121.1NT_037436.3 range: 7426988..7428278, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005525GTP bindingMolecular FunctionIEA
GO:0003924GTPase activityMolecular FunctionISS
GO:0003924GTPase activityMolecular FunctionNAS
GO:0003924GTPase activityMolecular FunctionTAS (10847683)
GO:0008258head involutionBiological ProcessIMP (15936337)
GO:0008104protein localizationBiological ProcessIMP
GO:0002009morphogenesis of an epitheliumBiological ProcessTAS (12147138)
GO:0008103oocyte microtubule cytoskeleton polarizationBiological ProcessIMP
GO:0030032lamellipodium biogenesisBiological ProcessIMP (15936337)
GO:0035010encapsulation of foreign targetBiological ProcessIMP (16098145)
GO:0035099hemocyte migrationBiological ProcessIMP (15699212)
GO:0042052rhabdomere developmentBiological ProcessIMP
GO:0045011actin cable formationBiological ProcessIMP (15936337)
GO:0045451pole plasm oskar mRNA localizationBiological ProcessIMP
GO:0007520myoblast fusionBiological ProcessTAS (12111720)
GO:0007426tracheal outgrowth, open tracheal systemBiological ProcessIGI (12588856)
GO:0002433phagocytosis triggered by activation of immune response cell surface activating receptorBiological ProcessIDA
GO:0006911phagocytosis, engulfmentBiological ProcessIMP (16336044)
GO:0007254JNK cascadeBiological ProcessIMP (15936337)
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0007390germ-band shorteningBiological ProcessIMP (15936337)
GO:0007391dorsal closureBiological ProcessIMP (15843408|15936337)
GO:0007391dorsal closureBiological ProcessTAS (12147138)
GO:0007394dorsal closure, elongation of leading edge cellsBiological ProcessIMP (15936337)
GO:0007424open tracheal system developmentBiological ProcessIGI (12588856)
GO:0050770regulation of axonogenesisBiological ProcessIGI (15572110)
Other Database Cross Links
NCBI Entrez Gene:38831