ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

38831

Symbol:

Rac2

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

66A1-66A1

Physical Location:

7426988-7428278 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rac2
Fold Change:		>2
P Value:		3.40E-08
Note:		Resistant line>Sensitive line

Dataset Information

Name:		17973985
Method:		Microarray
Phenotype:		Ethanol sensitivity
Publication:		Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:		We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_139864.1	NP_648121.1	NT_037436.3 range: 7426988..7428278, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	ISS
GO:0003924	GTPase activity	Molecular Function	NAS
GO:0003924	GTPase activity	Molecular Function	TAS (10847683)
GO:0008258	head involution	Biological Process	IMP (15936337)
GO:0008104	protein localization	Biological Process	IMP
GO:0002009	morphogenesis of an epithelium	Biological Process	TAS (12147138)
GO:0008103	oocyte microtubule cytoskeleton polarization	Biological Process	IMP
GO:0030032	lamellipodium biogenesis	Biological Process	IMP (15936337)
GO:0035010	encapsulation of foreign target	Biological Process	IMP (16098145)
GO:0035099	hemocyte migration	Biological Process	IMP (15699212)
GO:0042052	rhabdomere development	Biological Process	IMP
GO:0045011	actin cable formation	Biological Process	IMP (15936337)
GO:0045451	pole plasm oskar mRNA localization	Biological Process	IMP
GO:0007520	myoblast fusion	Biological Process	TAS (12111720)
GO:0007426	tracheal outgrowth, open tracheal system	Biological Process	IGI (12588856)
GO:0002433	phagocytosis triggered by activation of immune response cell surface activating receptor	Biological Process	IDA
GO:0006911	phagocytosis, engulfment	Biological Process	IMP (16336044)
GO:0007254	JNK cascade	Biological Process	IMP (15936337)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0007390	germ-band shortening	Biological Process	IMP (15936337)
GO:0007391	dorsal closure	Biological Process	IMP (15843408\|15936337)
GO:0007391	dorsal closure	Biological Process	TAS (12147138)
GO:0007394	dorsal closure, elongation of leading edge cells	Biological Process	IMP (15936337)
GO:0007424	open tracheal system development	Biological Process	IGI (12588856)
GO:0050770	regulation of axonogenesis	Biological Process	IGI (15572110)