ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG2064

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

43E9-43E9

Physical Location:

3553336-3554851 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 112724 Symbol (Name): RDH13 (retinol dehydrogenase 13 (all-trans/9-cis))

Ortholog Status:

The human GeneID 112724 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG2064
Fold Change:		>2
P Value:		2.81E-07
Note:		Sensitive line>Resistant line

Dataset Information

Name:		17973985
Method:		Microarray
Phenotype:		Ethanol sensitivity
Publication:		Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:		We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_136466.2	NP_610310.2	NT_033778.3 range: 3553336..3554851

Gene Ontology (GO) Annotation