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Gene Information
Gene ID:38013
Organism:Drosophila melanogaster (Fly)
Genetic Location:61A5-61A5
Physical Location:22946-26315 on NT_037436.3
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:mthl8
Fold Change:>2
P Value:8.22E-09
Note:Resistant line>Sensitive line
Gene Information
Original ID1:mthl8
Fold Change:>2
P Value:5.06E-07
Note:Resistant line>Sensitive line
Dataset Information
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_138154.2NP_611998.1NT_037436.3 range: 22946..26315
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentISS (10908591)
GO:0016021integral to membraneCellular ComponentNAS
GO:0004930G-protein coupled receptor activityMolecular FunctionISS (10908591)
GO:0006950response to stressBiological ProcessISS
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessISS (10908591)
GO:0008340determination of adult life spanBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:38013