ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mkp3

Alias:

CG14080|CG14081|DMKP-3|Dmkp3|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

75F6-75F6

Physical Location:

19060831-19079521 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1849 Symbol (Name): DUSP7 (dual specificity phosphatase 7)

Ortholog Status:

The human GeneID 1849 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mkp3
Fold Change:		>2
P Value:		2.72E-07
Note:		Resistant line>Sensitive line

Dataset Information

Name:		17973985
Method:		Microarray
Phenotype:		Ethanol sensitivity
Publication:		Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:		We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (11742539)
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Molecular Function	ISS
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IDA (11742539)
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Molecular Function	NAS (10908587)
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Molecular Function	ISS
GO:0007474	imaginal disc-derived wing vein specification	Biological Process	IMP (15704110)
GO:0007428	primary branching, open tracheal system	Biological Process	IMP (16831830)
GO:0016337	cell-cell adhesion	Biological Process	IMP (16831830)
GO:0006470	protein amino acid dephosphorylation	Biological Process	NAS (10908587)
GO:0006470	protein amino acid dephosphorylation	Biological Process	IDA (11742539)
GO:0035160	maintenance of epithelial integrity, open tracheal system	Biological Process	IMP (16831830)
GO:0043409	negative regulation of MAPKKK cascade	Biological Process	IMP (15704110)