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Gene Information
Gene ID:40081
Organism:Drosophila melanogaster (Fly)
Genetic Location:75F6-75F6
Physical Location:19060831-19079521 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1849    Symbol (Name): DUSP7 (dual specificity phosphatase 7)
Ortholog Status:The human GeneID 1849 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Mkp3
Fold Change:>2
P Value:2.72E-07
Note:Resistant line>Sensitive line
Dataset Information
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_140830.1NP_649087.1NT_037436.3 range: 19060831..19079521, complement
NM_168785.1NP_730385.1NT_037436.3 range: 19060831..19079521, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (11742539)
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activityMolecular FunctionISS
GO:0016791phosphoric monoester hydrolase activityMolecular FunctionIDA (11742539)
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionNAS (10908587)
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionISS
GO:0007474imaginal disc-derived wing vein specificationBiological ProcessIMP (15704110)
GO:0007428primary branching, open tracheal systemBiological ProcessIMP (16831830)
GO:0016337cell-cell adhesionBiological ProcessIMP (16831830)
GO:0006470protein amino acid dephosphorylationBiological ProcessNAS (10908587)
GO:0006470protein amino acid dephosphorylationBiological ProcessIDA (11742539)
GO:0035160maintenance of epithelial integrity, open tracheal systemBiological ProcessIMP (16831830)
GO:0043409negative regulation of MAPKKK cascadeBiological ProcessIMP (15704110)
Other Database Cross Links
NCBI Entrez Gene:40081