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Gene Information
Gene ID:45285
Symbol:Dr
Alias:153515_at|99B|CG1897|Msh|l(3)FA30|ltt|msh-1|msh1
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:99B3-99B3
Physical Location:25382108-25391006 on NT_033777.2
Gene Type:protein-coding
Human Ortholog:GeneID: 4487    Symbol (Name): MSX1 (msh homeobox 1)
Ortholog Status:The human GeneID 4487 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dr
P Value:3.16E-02
Note:Acute up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Information
Original ID1:Dr
Fold Change:>2
P Value:6.42E-07
Note:Resistant line>Sensitive line
Dataset Information
Name:17973985
Method:Microarray
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057976.2NP_477324.1NT_033777.2 range: 25382108..25391006
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentNAS
GO:0003677DNA bindingMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0007517muscle developmentBiological ProcessNAS
GO:0007517muscle developmentBiological ProcessTAS (12111720)
GO:0009953dorsal/ventral pattern formationBiological ProcessTAS (12593977|15221856)
GO:0021782glial cell developmentBiological ProcessIMP (17038517)
GO:0035222wing disc pattern formationBiological ProcessIMP (16093324)
GO:0035309wing and notum subfield formationBiological ProcessIMP (16093324)
GO:0042659regulation of cell fate specificationBiological ProcessIMP (11861486)
GO:0007476imaginal disc-derived wing morphogenesisBiological ProcessIMP (11546743)
GO:0007450dorsal/ventral pattern formation, imaginal discBiological ProcessIMP (11546743)
GO:0007420brain developmentBiological ProcessTAS (15221856)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0007389pattern specification processBiological ProcessNAS
GO:0007398ectoderm developmentBiological ProcessTAS (15221856)
GO:0007399nervous system developmentBiological ProcessNAS
GO:0007400neuroblast fate determinationBiological ProcessTAS (12593977)
GO:0007417central nervous system developmentBiological ProcessNAS
GO:0007419ventral cord developmentBiological ProcessNAS (12027434)
GO:0007419ventral cord developmentBiological ProcessTAS (12593977)
GO:0045449regulation of transcriptionBiological ProcessNAS (12027431)
Other Database Cross Links
NCBI Entrez Gene:45285
FLYBASE:FBgn0000492