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Gene Information
Gene ID:36047
Organism:Drosophila melanogaster (Fly)
Genetic Location:46D9-46D9
Physical Location:5941793-5942071 on NT_033778.3, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Def
Fold Change:>2
P Value:0.006961455
Note:Resistant line>Sensitive line
Dataset Information
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_078948.2NP_523672.1NT_033778.3 range: 5941793..5942071, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0006965positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteriaBiological ProcessNAS
GO:0019731antibacterial humoral responseBiological ProcessIEP (8168509)
GO:0019731antibacterial humoral responseBiological ProcessISS (8168509)
GO:0042742defense response to bacteriumBiological ProcessNAS (11283698)
GO:0042742defense response to bacteriumBiological ProcessTAS (8808632)
GO:0050830defense response to Gram-positive bacteriumBiological ProcessIDA (7588819)
GO:0050830defense response to Gram-positive bacteriumBiological ProcessTAS (10793472)
Other Database Cross Links
NCBI Entrez Gene:36047