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Gene Information
Gene ID:33277
Symbol:ia2
Alias:CG11344|CG31795|CG4355|R-PTPX/1A2|anon-WO0153538.69|unnamed
Organism:Drosophila melanogaster (Fly)
Chromosome:2L
Genetic Location:21E3-21E3
Physical Location:1011402-1048052 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5798    Symbol (Name): PTPRN (protein tyrosine phosphatase, receptor type, N)
Ortholog Status:The human GeneID 5798 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ia2
P Value:1.55E-02
Note:Slow up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Information
Original ID1:ia2
Fold Change:>2
P Value:2.71E-05
Note:Resistant line>Sensitive line
Dataset Information
Name:17973985
Method:Microarray
Phenotype:Ethanol sensitivity
Publication:Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134718.4NP_608562.3NT_033779.4 range: 1011402..1048052, complement
NM_164401.3NP_722672.2NT_033779.4 range: 1011402..1048052, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentISS
GO:0004725protein tyrosine phosphatase activityMolecular FunctionNAS (10908587)
GO:0005001transmembrane receptor protein tyrosine phosphatase activityMolecular FunctionISS
GO:0005001transmembrane receptor protein tyrosine phosphatase activityMolecular FunctionNAS
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessNAS (10908587)
Other Database Cross Links
NCBI Entrez Gene:33277
FLYBASE:FBgn0031294