ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ia2

Alias:

CG11344|CG31795|CG4355|R-PTPX/1A2|anon-WO0153538.69|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

21E3-21E3

Physical Location:

1011402-1048052 on NT_033779.4, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5798 Symbol (Name): PTPRN (protein tyrosine phosphatase, receptor type, N)

Ortholog Status:

The human GeneID 5798 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Information

Original ID1:		ia2
Fold Change:		>2
P Value:		2.71E-05
Note:		Resistant line>Sensitive line

Dataset Information

Name:		17973985
Method:		Microarray
Phenotype:		Ethanol sensitivity
Publication:		Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
Summary:		We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	NAS (10908587)
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Molecular Function	ISS
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Molecular Function	NAS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	NAS (10908587)