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Dataset Description
  • Dataset Name: 17973985
  • Species: Fly
  • Method: Microarray
  • No. of Genes: 109
  • Phenotype: Ethanol sensitivity
  • Publication: Morozova et al. Genome Biol. (2007) Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. PubMed
  • Dataset Summary: We performed artificial selection for alcohol sensitivity for 35 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues.

    Gene list of this dataset (109 genes)
    Page: 1 2 3 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    326169CG31883-30B10-30B10CG31883 
    36661Cyp6a23-51D1-51D1Cyp6a23 
    37054CG5770-55B1-55B1CG5770 
    37100IM1-55C4-55C4IM1 
    36486IM10-50A5-50A5IM10 
    35587Cyp6a2-42D1-42D1Cyp6a2 
    37099IM23-55C4-55C4IM23 
    326258CG33109-88A12-88A12CG33109 
    39510CG10725-70B1-70B1CG10725 
    36780Jhe-52E5-52E5Jhe 
    37313CG13422-57A4-57A4CG13422 
    318189CG32751-5D8-5D8CG32751 
    Page: 1 2 3 list all