ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

24681

Symbol:

Prkcc

Full Name:

protein kinase C, gamma

Alias:

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q12

Physical Location:

64145748-64172711 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5582 Symbol (Name): PRKCG (protein kinase C, gamma)

Ortholog Status:

The human GeneID 5582 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		24681
Fold Change:		1.655
P Value:		0.001
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012628.1	NP_036760.1	NC_005100.2 range: 64145748..64172711, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030425	dendrite	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IDA (14688616)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0030425	dendrite	Cellular Component	IEA
GO:0019717	synaptosome	Cellular Component	IDA (14688616)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004697	protein kinase C activity	Molecular Function	IDA (11507002)
GO:0004697	protein kinase C activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0019992	diacylglycerol binding	Molecular Function	IEA
GO:0032425	positive regulation of mismatch repair	Biological Process	ISS
GO:0031397	negative regulation of protein ubiquitination	Biological Process	IEA
GO:0031397	negative regulation of protein ubiquitination	Biological Process	ISS
GO:0032425	positive regulation of mismatch repair	Biological Process	IEA
GO:0042177	negative regulation of protein catabolic process	Biological Process	IEA
GO:0007635	chemosensory behavior	Biological Process	ISS
GO:0007635	chemosensory behavior	Biological Process	IEA
GO:0007611	learning and/or memory	Biological Process	IEP (12000125)
GO:0007268	synaptic transmission	Biological Process	NAS (14688616)
GO:0007242	intracellular signaling cascade	Biological Process	NAS (11507002)
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0042177	negative regulation of protein catabolic process	Biological Process	ISS