ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prps2

Full Name:

phosphoribosyl pyrophosphate synthetase 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

Xq21

Physical Location:

47274361-47315273 on NC_005120.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5634 Symbol (Name): PRPS2 (phosphoribosyl pyrophosphate synthetase 2)

Ortholog Status:

The human GeneID 5634 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Prps2
Fold Change:		-1.13
P Value:		0.007
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012634.1	NP_036766.1	NC_005120.2 range: 47274361..47315273

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043234	protein complex	Cellular Component	IDA (2546925)
GO:0005625	soluble fraction	Cellular Component	IDA (2546925)
GO:0019003	GDP binding	Molecular Function	IDA (9748490)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016208	AMP binding	Molecular Function	IDA (9748490)
GO:0000287	magnesium ion binding	Molecular Function	IDA (9748490)
GO:0005524	ATP binding	Molecular Function	IDA (2546925\|9748490)
GO:0005529	sugar binding	Molecular Function	IDA (2546925\|9748490)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004749	ribose phosphate diphosphokinase activity	Molecular Function	IDA (2546925\|9748490)
GO:0004749	ribose phosphate diphosphokinase activity	Molecular Function	IEA
GO:0006167	AMP biosynthetic process	Biological Process	IDA (2546925)
GO:0009165	nucleotide biosynthetic process	Biological Process	IEA
GO:0009165	nucleotide biosynthetic process	Biological Process	IDA (9748490)
GO:0009156	ribonucleoside monophosphate biosynthetic process	Biological Process	IEA
GO:0009116	nucleoside metabolic process	Biological Process	IEA