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Gene Information
Gene ID:24689
Full Name:phosphoribosyl pyrophosphate synthetase 2
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq21
Physical Location:47274361-47315273 on NC_005120.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5634    Symbol (Name): PRPS2 (phosphoribosyl pyrophosphate synthetase 2)
Ortholog Status:The human GeneID 5634 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Prps2
Fold Change:-1.13
P Value:0.007
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012634.1NP_036766.1NC_005120.2 range: 47274361..47315273
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043234protein complexCellular ComponentIDA (2546925)
GO:0005625soluble fractionCellular ComponentIDA (2546925)
GO:0019003GDP bindingMolecular FunctionIDA (9748490)
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0016208AMP bindingMolecular FunctionIDA (9748490)
GO:0000287magnesium ion bindingMolecular FunctionIDA (9748490)
GO:0005524ATP bindingMolecular FunctionIDA (2546925|9748490)
GO:0005529sugar bindingMolecular FunctionIDA (2546925|9748490)
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0004749ribose phosphate diphosphokinase activityMolecular FunctionIDA (2546925|9748490)
GO:0004749ribose phosphate diphosphokinase activityMolecular FunctionIEA
GO:0006167AMP biosynthetic processBiological ProcessIDA (2546925)
GO:0009165nucleotide biosynthetic processBiological ProcessIEA
GO:0009165nucleotide biosynthetic processBiological ProcessIDA (9748490)
GO:0009156ribonucleoside monophosphate biosynthetic processBiological ProcessIEA
GO:0009116nucleoside metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:24689