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Gene Information
Gene ID:24718
Full Name:reelin
Organism:Rattus norvegicus (Rat)
Genetic Location:4q11.2
Physical Location:8150872-8609140 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5649    Symbol (Name): RELN (reelin)
Ortholog Status:The human GeneID 5649 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Reln
Fold Change:-1.24
P Value:0.007
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_080394.2NP_536319.2NC_005103.2 range: 8150872..8609140
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0004712protein serine/threonine/tyrosine kinase activityMolecular FunctionISS
GO:0000904cellular morphogenesis during differentiationBiological ProcessISS
GO:0018108peptidyl-tyrosine phosphorylationBiological ProcessISS
GO:0021511spinal cord patterningBiological ProcessISS
GO:0021800cerebral cortex tangential migrationBiological ProcessISS
GO:0042403thyroid hormone metabolic processBiological ProcessISS
GO:0045860positive regulation of protein kinase activityBiological ProcessISS
GO:0048265response to painBiological ProcessISS
GO:0010001glial cell differentiationBiological ProcessISS
GO:0007626locomotory behaviorBiological ProcessISS
GO:0007626locomotory behaviorBiological ProcessIMP (12670697)
GO:0007420brain developmentBiological ProcessISS
GO:0007420brain developmentBiological ProcessIMP (2709802)
GO:0007417central nervous system developmentBiological ProcessISS
GO:0007411axon guidanceBiological ProcessISS
GO:0001764neuron migrationBiological ProcessISS
GO:0051057positive regulation of small GTPase mediated signal transductionBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24718