ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

24737

Symbol:

RT1-Aw2

Full Name:

RT1 class Ib, locus Aw2

Alias:

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20p12

Physical Location:

5056753-5060282 on NC_005119.2

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.83611
Fold Change:		1.94
P Value:		0
Note:		Lower levels in the hippocampus of iP than iNP rats

Gene Information

Original ID1:		Rn.39743
Original ID2:		RT1Aw2
Fold Change:		1.68
P Value:		0
Note:		Lower levels in the hippocampus of iP than iNP rats

Gene Information

Original ID1:		Rn.39743
Original ID2:		RT1Aw2
Fold Change:		1.53
P Value:		0
Note:		Lower levels in the hippocampus of iP than iNP rats

Gene Information

Original ID1:		Rn.39743
Original ID2:		RT1Aw2
Fold Change:		1.32
P Value:		0.00011
Note:		Lower levels in the hippocampus of iP than iNP rats

Gene Information

Original ID1:		Rn.39743
Original ID2:		RT1Aw2
Fold Change:		1.52
P Value:		0.0009
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Information

Original ID1:		RT1-Aw2
Fold Change:		-1.37
Tissue:		Accumbens

Gene Information

Original ID1:		RT1-Aw2
Fold Change:		-1.41
Tissue:		Amygdala

Gene Information

Original ID1:		RT1-Aw2
Fold Change:		-1.41
Tissue:		Hippocampus

Gene Information

Original ID1:		RT1-Aw2
Fold Change:		-1.39
Tissue:		Caudate-putamen

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012645.1	NP_036777.1	NC_005119.2 range: 5056753..5060282

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0005884	actin filament	Cellular Component	IEA
GO:0016272	prefoldin complex	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005581	collagen	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016605	PML body	Cellular Component	IEA
GO:0000792	heterochromatin	Cellular Component	IEA
GO:0001891	phagocytic cup	Cellular Component	IEA
GO:0042612	MHC class I protein complex	Cellular Component	IEA
GO:0042613	MHC class II protein complex	Cellular Component	IEA
GO:0001726	ruffle	Cellular Component	IEA
GO:0047485	protein N-terminus binding	Molecular Function	IEA
GO:0047915	ganglioside galactosyltransferase activity	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0050681	androgen receptor binding	Molecular Function	IEA
GO:0051082	unfolded protein binding	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	ISS
GO:0008134	transcription factor binding	Molecular Function	ISS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008378	galactosyltransferase activity	Molecular Function	IEA
GO:0046873	metal ion transmembrane transporter activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0016439	tRNA-pseudouridine synthase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0016564	transcription repressor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003707	steroid hormone receptor activity	Molecular Function	IEA
GO:0005201	extracellular matrix structural constituent	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005496	steroid binding	Molecular Function	IEA
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0004812	aminoacyl-tRNA ligase activity	Molecular Function	IEA
GO:0004832	valine-tRNA ligase activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0005125	cytokine activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0030521	androgen receptor signaling pathway	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process	IEA
GO:0000902	cell morphogenesis	Biological Process	IEA
GO:0000281	cytokinesis after mitosis	Biological Process	IEA
GO:0051017	actin filament bundle formation	Biological Process	IEA
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process	IEA
GO:0030001	metal ion transport	Biological Process	IEA
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	Biological Process	IEA
GO:0019882	antigen processing and presentation	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006418	tRNA aminoacylation for protein translation	Biological Process	IEA
GO:0006438	valyl-tRNA aminoacylation	Biological Process	IEA
GO:0006486	protein amino acid glycosylation	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006817	phosphate transport	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006457	protein folding	Biological Process	IEA
GO:0006281	DNA repair	Biological Process	IEA