ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Scn2a1

Full Name:

sodium channel, voltage-gated, type II, alpha 1

Alias:

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q24

Physical Location:

47588410-47722799 on NC_005102.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6325 Symbol (Name): ()

Ortholog Status:

The human GeneID 6325 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		24766
Fold Change:		0.709
P Value:		0.0455
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012647.1	NP_036779.1	NC_005102.2 range: 47588410..47722799

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0001518	voltage-gated sodium channel complex	Cellular Component	IDA (2442385\|15664695)
GO:0030424	axon	Cellular Component	ISS
GO:0030315	T-tubule	Cellular Component	ISS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0014704	intercalated disc	Cellular Component	ISS
GO:0031402	sodium ion binding	Molecular Function	IDA (15664695)
GO:0005248	voltage-gated sodium channel activity	Molecular Function	IDA (2442385\|15664695)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005248	voltage-gated sodium channel activity	Molecular Function	IC (15917456)
GO:0005248	voltage-gated sodium channel activity	Molecular Function	ISS
GO:0019228	regulation of action potential in neuron	Biological Process	TAS (3754035)
GO:0019228	regulation of action potential in neuron	Biological Process	IDA (15664695\|15917456)
GO:0006814	sodium ion transport	Biological Process	ISS
GO:0006811	ion transport	Biological Process	IEA
GO:0007399	nervous system development	Biological Process	ISS
GO:0006814	sodium ion transport	Biological Process	IDA (2442385)
GO:0006915	apoptosis	Biological Process	ISS