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Gene Information
Gene ID:24766
Full Name:sodium channel, voltage-gated, type II, alpha 1
Organism:Rattus norvegicus (Rat)
Genetic Location:3q24
Physical Location:47588410-47722799 on NC_005102.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6325    Symbol (Name): ()
Ortholog Status:The human GeneID 6325 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:24766
Fold Change:0.709
P Value:0.0455
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012647.1NP_036779.1NC_005102.2 range: 47588410..47722799
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001518voltage-gated sodium channel complexCellular ComponentIDA (2442385|15664695)
GO:0030424axonCellular ComponentISS
GO:0030315T-tubuleCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005624membrane fractionCellular ComponentISS
GO:0014704intercalated discCellular ComponentISS
GO:0031402sodium ion bindingMolecular FunctionIDA (15664695)
GO:0005248voltage-gated sodium channel activityMolecular FunctionIDA (2442385|15664695)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005248voltage-gated sodium channel activityMolecular FunctionIC (15917456)
GO:0005248voltage-gated sodium channel activityMolecular FunctionISS
GO:0019228regulation of action potential in neuronBiological ProcessTAS (3754035)
GO:0019228regulation of action potential in neuronBiological ProcessIDA (15664695|15917456)
GO:0006814sodium ion transportBiological ProcessISS
GO:0006811ion transportBiological ProcessIEA
GO:0007399nervous system developmentBiological ProcessISS
GO:0006814sodium ion transportBiological ProcessIDA (2442385)
GO:0006915apoptosisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24766