ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gabrb3

Full Name:

gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q22

Physical Location:

109047407-109277755 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2562 Symbol (Name): GABRB3 (gamma-aminobutyric acid (GABA) A receptor, beta 3)

Ortholog Status:

The human GeneID 2562 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gabrb3
Fold Change:		-1.33
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017065.1	NP_058761.1	NC_005100.2 range: 109047407..109277755

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (15474980)
GO:0043195	terminal button	Cellular Component	IDA (12812758)
GO:0045202	synapse	Cellular Component	IEA
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0004890	GABA-A receptor activity	Molecular Function	IDA (2548852\|12356876\|15152020)
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12812758)
GO:0004890	GABA-A receptor activity	Molecular Function	IEA
GO:0004890	GABA-A receptor activity	Molecular Function	TAS (11161482)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005254	chloride channel activity	Molecular Function	IDA (12356876)
GO:0005254	chloride channel activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (16192353)
GO:0006811	ion transport	Biological Process	IEA
GO:0051932	synaptic transmission, GABAergic	Biological Process	IDA (12356876)