ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Plp1

Full Name:

proteolipid protein (myelin) 1

Alias:

Plp

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

Xq35

Physical Location:

124488626-124503638 on NC_005120.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5354 Symbol (Name): PLP1 (proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated))

Ortholog Status:

The human GeneID 5354 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Plp
Fold Change:		1.15
P Value:		0.006
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Plp
Fold Change:		1.14
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_030990.1	NP_112252.1	NC_005120.2 range: 124488626..124503638

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043218	compact myelin	Cellular Component	IMP (3476944)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (12196561)
GO:0043209	myelin sheath	Cellular Component	ISS
GO:0005198	structural molecule activity	Molecular Function	IDA (12196561)
GO:0019911	structural constituent of myelin sheath	Molecular Function	IMP (3476944)
GO:0005515	protein binding	Molecular Function	ISS
GO:0008366	axon ensheathment	Biological Process	ISS
GO:0007229	integrin-mediated signaling pathway	Biological Process	IPI (12196561)
GO:0042759	long-chain fatty acid biosynthetic process	Biological Process	ISS
GO:0042552	myelination	Biological Process	ISS
GO:0042552	myelination	Biological Process	IMP (3476944)
GO:0022010	myelination in the central nervous system	Biological Process	ISS
GO:0008366	axon ensheathment	Biological Process	IEP (12196561)
GO:0010001	glial cell differentiation	Biological Process	IMP (1384273\|7674382)
GO:0048469	cell maturation	Biological Process	ISS