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Gene Information
Gene ID:24943
Full Name:proteolipid protein (myelin) 1
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq35
Physical Location:124488626-124503638 on NC_005120.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5354    Symbol (Name): PLP1 (proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated))
Ortholog Status:The human GeneID 5354 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Plp
Fold Change:1.15
P Value:0.006
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Plp
Fold Change:1.14
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_030990.1NP_112252.1NC_005120.2 range: 124488626..124503638
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043218compact myelinCellular ComponentIMP (3476944)
GO:0005887integral to plasma membraneCellular ComponentTAS (12196561)
GO:0043209myelin sheathCellular ComponentISS
GO:0005198structural molecule activityMolecular FunctionIDA (12196561)
GO:0019911structural constituent of myelin sheathMolecular FunctionIMP (3476944)
GO:0005515protein bindingMolecular FunctionISS
GO:0008366axon ensheathmentBiological ProcessISS
GO:0007229integrin-mediated signaling pathwayBiological ProcessIPI (12196561)
GO:0042759long-chain fatty acid biosynthetic processBiological ProcessISS
GO:0042552myelinationBiological ProcessISS
GO:0042552myelinationBiological ProcessIMP (3476944)
GO:0022010myelination in the central nervous systemBiological ProcessISS
GO:0008366axon ensheathmentBiological ProcessIEP (12196561)
GO:0010001glial cell differentiationBiological ProcessIMP (1384273|7674382)
GO:0048469cell maturationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24943