ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Glul

Full Name:

glutamate-ammonia ligase (glutamine synthetase)

Alias:

Glns

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q22

Physical Location:

32898168-32924845 on NC_005111.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2752 Symbol (Name): GLUL (glutamate-ammonia ligase (glutamine synthetase))

Ortholog Status:

The human GeneID 2752 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Glul
Fold Change:		1.14
P Value:		0.008
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_001053012.1	XP_001053012.1	NC_005111.2 range: 32898168..32924845

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0004356	glutamate-ammonia ligase activity	Molecular Function	IEA
GO:0004356	glutamate-ammonia ligase activity	Molecular Function	TAS (1674354)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0019676	ammonia assimilation cycle	Biological Process	TAS (1674354)
GO:0009749	response to glucose stimulus	Biological Process	ISS
GO:0006807	nitrogen compound metabolic process	Biological Process	IEA
GO:0006542	glutamine biosynthetic process	Biological Process	IEA
GO:0042133	neurotransmitter metabolic process	Biological Process	TAS (1674354)