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Gene Information
Gene ID:24957
Full Name:glutamate-ammonia ligase (glutamine synthetase)
Organism:Rattus norvegicus (Rat)
Genetic Location:13q22
Physical Location:32898168-32924845 on NC_005111.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2752    Symbol (Name): GLUL (glutamate-ammonia ligase (glutamine synthetase))
Ortholog Status:The human GeneID 2752 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Glul
Fold Change:1.14
P Value:0.008
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_001053012.1XP_001053012.1NC_005111.2 range: 32898168..32924845
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentISS
GO:0004356glutamate-ammonia ligase activityMolecular FunctionIEA
GO:0004356glutamate-ammonia ligase activityMolecular FunctionTAS (1674354)
GO:0016874ligase activityMolecular FunctionIEA
GO:0019676ammonia assimilation cycleBiological ProcessTAS (1674354)
GO:0009749response to glucose stimulusBiological ProcessISS
GO:0006807nitrogen compound metabolic processBiological ProcessIEA
GO:0006542glutamine biosynthetic processBiological ProcessIEA
GO:0042133neurotransmitter metabolic processBiological ProcessTAS (1674354)
Other Database Cross Links
NCBI Entrez Gene:24957